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In this release, we profited from a nearly doubled volume of published in vivo experiments on transcription factor (TF) binding to expand the repertoire of binding models, replace low-quality models previously based on in vitro data only and cover more than a hundred TFs with previously unknown binding specificities.

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We present a major update of the HOCOMOCO collection that consists of patterns describing DNA binding specificities for human and mouse transcription factors.

11 King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center (CBRC), Thuwal 23955-6900, Saudi Arabia.

(CBBD-OIL), AIST Tokyo Waterfront Main Bldg.

10 National Institute of Advanced Industrial Science and Technology (AIST), Com.

9 Institute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071, 2 Leninsky Ave.

8 Moscow Institute of Physics and Technology (State University), 141700, 9 Institutskiy per, Dolgoprudny, Russia.

7 Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119234, Leninskiye Gory 1-73, Moscow, Russia.

6 Novosibirsk State University, 630090, Pirogova 2, Novosibirsk, Russia.

5 Institute of Computational Technologies, Siberian Branch of the Russian Academy of Sciences, 630090, Akad.

4 BIOSOFT.RU Ltd, 630058, Russkaya 41/1, Novosibirsk, Russia.

3 Center for Data-Intensive Biomedicine and Biotechnology, Skolkovo Institute of Science and Technology, 143026 Moscow, Russia.

2 Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991, GSP-1, Gubkina 3, Moscow, Russia.

1 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, GSP-1, Vavilova 32, Moscow, Russia.

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